Varma R S, Kapoor A
Pharmazie. 1980 Feb;35(2):78-80. doi: 10.1002/chin.198025208.
4-Aminodiphenyl ethers (2) obtained by reducing the corresponding nitro analogue (1), have been incorporated into benzazoles, phthalimides and 4-quinazolone in the presence of 40% formalin to furnish a series of 4-(3-benzazolymethyl)aminodiphenyl ethers (3) under the conditions of the Mannich reaction. In an alternate procedure, 3 were obtained on refluxing the N-hydroxymethyl derivatives of benzazoles etc. with 2 in methanol. A few amine exchange reactions were also performed and the stability of a few representative compounds was studied in different acidic media. The antibacterial spectrum of all the synthesized compounds was determined against Bacillus subtilis as well as Bacillus pumilus by the agar diffusion technique.
