Hemmingsen R, Kramp P
Psychopharmacology (Berl). 1980;67(3):255-9. doi: 10.1007/BF00431266.
Effects of ethanol intoxication and withdrawal on magnesium and calcium metabolism were studied in rats. During acute ethanol intoxication, plasma [Mg2+] was increased and plasma [Ca2+] decreased. During chronic intoxication, plasma [Mg2+] was normalized whereas plasma [Ca2+] was persistently subnormal. Ethanol withdrawal was followed by a decrease in plasma [Mg2+] and a normalization of plasma [Ca2+]. These various changes are probably related to changes in systemic pH and to the biochemical effects of ethanol and ethanol withdrawal on intermediary metabolism. Cerebrospinal fluid [Mg2+] was unchanged during intoxication and withdrawal and it was concluded that no etiological role can presently be ascribed to the magnesium ion as far as cerebral signs of ethanol intoxication and withdrawal in the rat are concerned. No consistent changes in erythrocyte [Mg2+] were encountered during ethanol intoxication and withdrawal in rats.
研究了乙醇中毒和戒断对大鼠镁和钙代谢的影响。在急性乙醇中毒期间，血浆[Mg2+]升高而血浆[Ca2+]降低。在慢性中毒期间，血浆[Mg2+]恢复正常，而血浆[Ca2+]持续低于正常水平。乙醇戒断后，血浆[Mg2+]降低，血浆[Ca2+]恢复正常。这些不同的变化可能与全身pH值的变化以及乙醇和乙醇戒断对中间代谢的生化影响有关。在中毒和戒断期间，脑脊液[Mg2+]没有变化，得出的结论是，就大鼠乙醇中毒和戒断的脑症状而言，目前不能将病因作用归因于镁离子。在大鼠乙醇中毒和戒断期间，红细胞[Mg2+]没有一致的变化。
