Hemmingsen R, Sørensen S C
Acta Pharmacol Toxicol (Copenh). 1980 Jan;46(1):62-5. doi: 10.1111/j.1600-0773.1980.tb02421.x.
Experimental and clinical results suggest a relationship between the action of ethanol and opiates. Therefore, we have tested whether the specific morphine antagonist naloxone (2 mg/kg intraperitoneally every six hours) affects signs of severe ethanol intoxication or modifies the withdrawal syndrome following chronic ethanol intoxication in rats. Using a double blind technique, we did not find any difference between saline treated and naloxone treated animals with respect to level of intoxication and severity of withdrawal symptoms. We must therefore conclude that naloxone does not modify signs of severe ethanol intoxication or change the ethanol withdrawal syndrome in the rat. These findings do not rule out that there might be a biochemical link between actions of ethanol and opiates, but this link is probably not localized at the level of specific drug receptor interaction.
实验和临床结果表明乙醇与阿片类药物的作用之间存在关联。因此，我们测试了特定的吗啡拮抗剂纳洛酮（每6小时腹腔注射2毫克/千克）是否会影响大鼠严重乙醇中毒的体征，或改变慢性乙醇中毒后的戒断综合征。采用双盲技术，我们发现生理盐水处理组和纳洛酮处理组动物在中毒程度和戒断症状严重程度方面没有差异。因此，我们必须得出结论，纳洛酮不会改变大鼠严重乙醇中毒的体征或改变乙醇戒断综合征。这些发现并不排除乙醇和阿片类药物的作用之间可能存在生化联系，但这种联系可能并不局限于特定药物受体相互作用的层面。
