Shannon H E
Psychopharmacology (Berl). 1980;67(3):311-2. doi: 10.1007/BF00431274.
3,4-Methylenedioxyamphetamine (MDA) and 2,5-dimethoxy-4-methylamphetamine (DOM) are amphetamine congeners that produce both amphetamine-like and LSD-like effects. To evaluate whether MDA and DOM should be classed with amphetamine, their capacity to produce amphetamine-like discriminative stimuli was assessed. Rats were trained to discriminate between saline and 1.0 mg/kg d-amphetamine in a two choice, discrete trial shock avoidance paradigm. Neither MDA nor DOM produced any amphetamine-appropriate responding when tested over a 30-fold dose range. The specificity of the procedure to detect amphetamine-like effects was demonstrated by the failure of LSD to produce any amphetamine-appropriate responding. These results suggest that neither MDA nor DOM should be classed as amphetamine-like agents.
3,4-亚甲二氧基苯丙胺（MDA）和2,5-二甲氧基-4-甲基苯丙胺（DOM）是苯丙胺同系物，会产生类似苯丙胺和类似麦角酸二乙酰胺（LSD）的效应。为评估MDA和DOM是否应归类于苯丙胺类，对它们产生类似苯丙胺辨别刺激的能力进行了评估。在双选择、离散试验电击回避范式中，训练大鼠区分生理盐水和1.0毫克/千克右旋苯丙胺。在30倍剂量范围内进行测试时，MDA和DOM均未产生任何与苯丙胺相符的反应。LSD未能产生任何与苯丙胺相符的反应，证明了该程序检测类似苯丙胺效应的特异性。这些结果表明，MDA和DOM均不应归类为类似苯丙胺的药物。
