Tilson H A, Baker T G, Gylys J A
Psychopharmacologia. 1975 Nov 21;44(3):225-8. doi: 10.1007/BF00428898.
The effects of 0.75 mg/kg of R-DOM and 1.0 mg/kg of S-amphetamine served as discriminative stimuli in the control of a two-lever discrimination response. Dose-response evaluation of the two agents indicated that in S-amphetamine-trained animals the drug effects produced by test doses of 0.5 to 2.2 mg/kg of S-amphetamine could be considered as a dose-dependent continuum of low to high stimulus intensity. In R-DOM trained subjects, low to moderate doses of R-DOM (0.5-1.5 mg/kg) produced dose-related discriminative responding, but the high dose of R-DOM (2.2 mg/kg) resulted in random responding. When animals trained to discriminate 1.0 mg/kg of S-amphetamine from saline were given 0.5 or 0.75 mg/kg of R-DOM, they tended to respond on the drug correct lever. However, higher doses of R-DOM (1.5 and 2.2 mg/kg) produced random responding. Similarly, animals trained to discriminate 0.75 mg/kg of R-DOM from saline exhibited correct responses following 0.5 and 0.75 mg/kg of S-amphetamine, but not after 1.5 and 2.2 mg/kg. These data suggest that low doses of R-DOM produce discriminative stimuli that are qualitatively different from those of higher doses. Stimuli following low doses of R-DOM also appear similar in some respects to those following low doses of S-amphetamine.
0.75毫克/千克的R - DOM和1.0毫克/千克的S - 苯丙胺的作用作为双杠杆辨别反应控制中的辨别性刺激。对这两种药物的剂量反应评估表明，在接受S - 苯丙胺训练的动物中，0.5至2.2毫克/千克测试剂量的S - 苯丙胺产生的药物效应可被视为低到高刺激强度的剂量依赖性连续体。在接受R - DOM训练的受试者中，低至中等剂量的R - DOM（0.5 - 1.5毫克/千克）产生与剂量相关的辨别反应，但高剂量的R - DOM（2.2毫克/千克）导致随机反应。当训练动物从生理盐水辨别出1.0毫克/千克的S - 苯丙胺并给予0.5或0.75毫克/千克的R - DOM时，它们倾向于在药物正确的杠杆上做出反应。然而，更高剂量的R - DOM（1.5和2.2毫克/千克）产生随机反应。同样，训练动物从生理盐水中辨别出0.75毫克/千克的R - DOM，在给予0.5和0.75毫克/千克的S - 苯丙胺后表现出正确反应，但在给予1.5和2.2毫克/千克后则没有。这些数据表明，低剂量的R - DOM产生的辨别性刺激在性质上与高剂量的不同。低剂量R - DOM后的刺激在某些方面也似乎与低剂量S - 苯丙胺后的刺激相似。
