Commissaris R, Lyness W H, Cordon J J, Moore K E, Rech R H
Pharmacol Biochem Behav. 1980 Nov;13(5):621-6. doi: 10.1016/0091-3057(80)90002-7.
The purpose of the present study was to determine the role of central catecholaminergic neuronal systems in the effects of LSD, DOM and d-amphetamine on fixed ratio (FR) operant responding in rats. Food-deprived male rats were trained to press a bar for food reinforcement on a FR-40 schedule. Control responding on this schedule is characterized by a rapid, constant rate of responding (approximately 100 responses/min) throughout a 40 min test session. LSD and DOM, as with other hallucinogens, produced dose-dependent periods of nonresponding or "pausing," followed by reinstatement of responding at or near the control rate. Administration of the non-hallucinogen, d-amphetamine, did not produce "pausing," but caused the response rate to slow and become erratic. In animals pretreated intraventricularly with 6-hydroxydopamine (6-OHDA; 200 micrograms/10 microliter X 2), the response to LSD and DOM was unchanged, while the response to d-amphetamine was significantly diminished. The neurotoxin significantly decreased brain catecholamines to less than 25 percent of control in al regions examined, without altering 5-HT concentrations in these same regions. These data demonstrate that the effects of LSD and DOM on FR-40 responding are quite different from those of d-amphetamine, and that this difference may be due to the extent of catecholamine involvement in the effects of these agents.
本研究的目的是确定中枢儿茶酚胺能神经元系统在麦角酸二乙胺（LSD）、2,5-二甲氧基-4-甲基苯丙胺（DOM）和右旋苯丙胺对大鼠固定比率（FR）操作性反应的影响中所起的作用。将禁食的雄性大鼠训练在FR-40程序下按压杠杆以获取食物强化。在此程序下的对照反应的特征是在整个40分钟的测试过程中反应速度快速且恒定（约100次反应/分钟）。与其他致幻剂一样，LSD和DOM产生剂量依赖性的无反应期或“暂停”期，随后以接近对照速度恢复反应。给予非致幻剂右旋苯丙胺不会产生“暂停”，但会导致反应速度减慢并变得不稳定。在脑室内预先用6-羟基多巴胺（6-OHDA；200微克/10微升×2）处理的动物中，对LSD和DOM的反应未改变，而对右旋苯丙胺的反应显著减弱。这种神经毒素使所检查的所有区域的脑儿茶酚胺显著降低至对照的25%以下，而这些相同区域的5-羟色胺浓度未改变。这些数据表明，LSD和DOM对FR-40反应的影响与右旋苯丙胺的影响有很大不同，这种差异可能是由于儿茶酚胺参与这些药物作用的程度不同所致。
