Mel'nichuk D A
Ukr Biokhim Zh (1978). 1980 Mar-Apr;52(2):150-4.
The paper deals with generalization of data from literature and results of own studies concerned with peculiarities in the course of main metabolic processes in people and animals under conditions of acidoses and alcaloses of an organism as compared to the normal level. Certain detected peculiarities of the metabolism the author considers as molecular homeostatic mechanisms of a cell which prevent to a considerable extent a sharp shift in pH of biological fluids. Attention is concentrated on the important independent regulatory significance of the HCO3- and CO2 concentrations in the cell for metabolism (independently of the pH value of tissue fluids). Possible applied importance of the detected metabolic peculiarities with the disturbance of acid-base balance in the human and animal organism is under discussion.
本文探讨了文献数据的概括以及自身研究结果，这些研究涉及与正常水平相比，机体处于酸中毒和碱中毒状态下人和动物主要代谢过程的特点。作者认为某些检测到的代谢特点是细胞的分子稳态机制，在很大程度上可防止生物体液pH值的急剧变化。注意力集中在细胞中HCO3-和CO2浓度对代谢的重要独立调节意义（与组织液的pH值无关）。文中还讨论了所检测到的代谢特点在人和动物机体酸碱平衡紊乱方面可能具有的应用重要性。
