Mel'nichuk D A
Ukr Biokhim Zh (1978). 1989 May-Jun;61(3):3-21.
Peculiarities of carbohydrate, lipid, amino acid nucleotide metabolism, of the tricarboxylic acid cycle functioning and of the oxidative phosphorylation have been studied in man and animals under conditions of changes in the acid-base equilibrium (ABE) state in the organism. The results of studies are analyzed and generalized. Strictly defined peculiarities of changes in the mentioned aspects of metabolism depending on the ABE state in the organism are revealed. Basing on a new interpretation of the experimental data and detected regularities in the metabolism, the author has drawn a conclusion on the existence of the previously unknown system of acid-base homeostasis in tissues. The physiological sense of this system functioning is the regulation of the intracellular acid-base equilibrium stability. The regulation mechanisms promoting functioning of this system are discussed. The system is shown to be of great applied significance for improvement of methods to cure a number of human and animal diseases as well as for an increase of the productivity of animals.
在机体酸碱平衡（ABE）状态发生变化的条件下，对人和动物体内碳水化合物、脂质、氨基酸核苷酸代谢、三羧酸循环功能及氧化磷酸化的特点进行了研究。对研究结果进行了分析和总结。揭示了上述代谢方面的变化严格取决于机体ABE状态的特点。基于对实验数据的新解释以及在代谢中检测到的规律，作者得出结论，组织中存在以前未知的酸碱稳态系统。该系统功能的生理意义在于调节细胞内酸碱平衡的稳定性。讨论了促进该系统功能的调节机制。该系统对改进治疗多种人类和动物疾病的方法以及提高动物生产力具有重要的应用意义。
