Abdukhalykova G F, Andreeva I V, Belitskiĭ G A, Skavronskaia A G
Biull Eksp Biol Med. 1980 Apr;89(4):468-70.
The carcinogenic polycyclic aromatic hydrocarbons have been shown to induce frameshift mutations rather than base-pair substitutions in Ames test strains devoid of pKM101 plasmid. This plasmid enhances the frequency of induced frameshift mutations and mediates the induction of base-pair substitutions during the action of these carcinogens. No correlation was observed between the degree of mutagenesis induced in plasmid-containing and in plasmid-free strains by the test agents and their reported carcinogenic activity.
已证明致癌多环芳烃在不含pKM101质粒的艾姆斯试验菌株中诱导移码突变而非碱基对置换。该质粒可提高诱导移码突变的频率，并在这些致癌物作用过程中介导碱基对置换的诱导。未观察到受试物在含质粒菌株和无质粒菌株中诱导的诱变程度与其报告的致癌活性之间存在相关性。
