Warner P F, Zubrzycki L J, Chila M
J Gen Microbiol. 1980 Mar;117(1):103-10. doi: 10.1099/00221287-117-1-103.
The genetic basis for spontaneous resistance to tetracyline (Tet) and penicillin (Pen) in Neisseria gonorrhoeae was investigated. Tet and pen are polygenes which confer small but distinct levels of resistance to Tet and Pen, respectively. Mtr is a multiple-drug resistance polygene which increases resistance to Tet and Pen (as well as to other unrelated antibiotics). Tem is a modifier gene affecting resistance toTet and Pen. Pem is a modifier gene for Pen resistance. The following gene combinations code for resistance to five antibiotics: tet, mtr and tem for Tet; pen, mtr, pem and tem for Pen; tet, tem and mtr for doxycycline; pen and pem for ampicillin; pen, pem and mtr for nafcillin.
研究了淋病奈瑟菌对四环素（Tet）和青霉素（Pen）自发耐药的遗传基础。Tet和pen是多基因，分别赋予对Tet和Pen小但明显的耐药水平。Mtr是一个多药耐药多基因，可增加对Tet和Pen（以及其他无关抗生素）的耐药性。Tem是一个影响对Tet和Pen耐药性的修饰基因。Pem是Pen耐药性的修饰基因。以下基因组合编码对五种抗生素的耐药性：对Tet为tet、mtr和tem；对Pen为pen、mtr、pem和tem；对强力霉素为tet、tem和mtr；对氨苄青霉素为pen和pem；对萘夫西林为pen、pem和mtr。
