淋病奈瑟菌中相关抗生素抗性基因座的遗传图谱分析
Genetic mapping of linked antibiotic resistance loci in Neisseria gonorrhoeae.
作者信息
Sarubbi F A, Blackman E, Sparling P F
出版信息
J Bacteriol. 1974 Dec;120(3):1284-92. doi: 10.1128/jb.120.3.1284-1292.1974.
Abstract
Loci for resistance to several antibiotics in laboratory-derived strains of Neisseria gonorrhoeae were mapped by genetic transformation. Genes for high-level resistance to streptomycin (str) and spectinomycin (spc) and for low-level resistance to tetracycline (tet) and chloramphenicol (chl) were linked. Also, a locus for high-level resistance to rifampin (rif) was linked to str and tet. The apparent order was rif... str... tet... chl... spc. Loci for resistance to other antibiotics (penicillin, erythromycin) were transferred independently of each other and were not linked to the cluster around str. Similar linkage relationships were found with str, tet, chl, and spc loci obtained from naturally occurring (clinical) isolates of N. gonorrhoeae.
摘要
通过基因转化对实验室衍生的淋病奈瑟菌菌株中几种抗生素的耐药位点进行了定位。对链霉素（str）和壮观霉素（spc）具有高水平抗性以及对四环素（tet）和氯霉素（chl）具有低水平抗性的基因是连锁的。此外，对利福平（rif）具有高水平抗性的位点与str和tet连锁。明显的顺序是rif...str...tet...chl...spc。对其他抗生素（青霉素、红霉素）的耐药位点相互独立转移，并且与str周围的簇不连锁。从淋病奈瑟菌的自然发生（临床）分离株获得的str、tet、chl和spc位点也发现了类似的连锁关系。
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Multiple antibiotic resistance due to a single mutation in Neisseria gonorrhoeae.淋病奈瑟菌单一突变导致多重抗生素耐药性。
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