Brunner D, Weisbord J, Meshulam N, Margulis S
MMW Munch Med Wochenschr. 1980 May 23;122(21):801-6.
The aim of this study was to examine the duration of action of a single cutaneous application of a 10% isosorbide dinitrate ointment (ISDN-S) and also to ascertain the possible appearance of nitrate tolerance after 6--8 months' maintenance therapy with ISDN-S. After a single application of the ointment an effect lasting more than 7 hours was confirmed by bicycle ergometry. After longterm therapy an acute test with rapidly acting sublingual ISDN produced an undiminished response thus showing lack of nitrate tolerance.
本研究的目的是检测单次皮肤涂抹10%硝酸异山梨酯软膏（ISDN-S）的作用持续时间，并确定ISDN-S维持治疗6 - 8个月后是否可能出现硝酸盐耐受性。单次涂抹该软膏后，通过自行车测力计证实效果持续超过7小时。长期治疗后，用速效舌下含服ISDN进行急性试验，结果显示反应未减弱，表明不存在硝酸盐耐受性。
