Meier H, Willital G H
MMW Munch Med Wochenschr. 1980 Feb 15;122(7):243-6.
76 children were treated with clindamycin at a dosage of 40 mg/kg/day for postsurgical wound infections, sepsis, phlegmon, peritonitis, osteomyelitis, pneumonia, mediastinitis, pyoderma and urinary tract infections. Frequency distribution of individual infectious agents: Staphylococci, 94,7%; Streptococci, 59,2%; Pneumococci, 5,3%; Enteroccocci, 25%; Escherichia coli, 10,5%; Pseudomonas, 14,5%; Proteus, 7,9%; Bacteroides, 6,6%; Clostridia, 7,9%. Therapy was successful in 83% of cases. Results were poor in 2 children treated for phlegmona, one case of mediastinitis and one of urinary tract infection, since organisms were predominantly gram-negative.
76名儿童因术后伤口感染、败血症、蜂窝织炎、腹膜炎、骨髓炎、肺炎、纵隔炎、脓皮病和尿路感染接受了剂量为40mg/kg/天的克林霉素治疗。个体感染病原体的频率分布：葡萄球菌，94.7%；链球菌，59.2%；肺炎球菌，5.3%；肠球菌，25%；大肠杆菌，10.5%；假单胞菌，14.5%；变形杆菌，7.9%；拟杆菌，6.6%；梭菌，7.9%。83%的病例治疗成功。两名因蜂窝织炎、一例纵隔炎和一例尿路感染接受治疗的儿童治疗效果不佳，因为病原体主要是革兰氏阴性菌。
