Bonser R S, Ghose R R
Postgrad Med J. 1980 Feb;56(652):121-3. doi: 10.1136/pgmj.56.652.121.
A patient with long-standing ischaemic heart disease and severe low output congestive cardiac failure received numerous diuretics, which gradually became ineffective. Resistant oedema was treated by adding demeclocycline to the current diuretic regime of frusemide and metolazone. Diuresis resulted, oedema disappeared and body weight fell. This drug combination was continued without complication for a further 6 months until his death.
一位患有长期缺血性心脏病和严重低输出量充血性心力衰竭的患者接受了多种利尿剂治疗，但这些利尿剂逐渐失效。通过在当前使用速尿和美托拉宗的利尿方案中添加地美环素，治疗顽固性水肿。利尿作用产生，水肿消失，体重下降。这种药物组合持续使用6个月无并发症，直至患者死亡。
