Ali S F, Chandra O, Hasan M
Psychopharmacology (Berl). 1980;68(1):37-42. doi: 10.1007/BF00426647.
Dichlorvos (O,O-dimethyl-2:2-dichlorovinyl phosphate) was administered IP (3 mg/kg) daily for 10 days to a group of albino rats. Open field behavior was significantly depressed below the mean of the control group. On day 7, ambulation was reduced to 24% of the mean but recovered to 60% on day 10. Similarly, rearing response was decreased on day 7 and showed a fast recovery on day 10 but the preening response further declined on day 10. Defecation, on the contrary, was suppressed to 0% on day 7 and showed complete recovery on day 10. Motor activity showed a significant depression and fine movements were reduced more than gross movements in the second phase. Dopamine was significantly decreased on days 5 and 7 but showed a 13% recovery in the brain stem on day 10. Norepinephrine was significantly reduced in the cerebral hemisphere while serotonin was decreased both in cerebral hemisphere and brain stem. Neither of thse two amines showed significant recovery on day 10. Interesting concordance of the open field behavioral changes with the levels of dopamine, norepinephrine, and serotonin in the various regions of the rat brain was noticeable and has been discussed.
将敌敌畏（O,O-二甲基-2,2-二氯乙烯基磷酸酯）以3毫克/千克的剂量腹腔注射，每天一次，连续10天给予一组白化大鼠。旷场行为明显低于对照组平均值。在第7天，走动减少至平均值的24%，但在第10天恢复到60%。同样，竖毛反应在第7天下降，并在第10天迅速恢复，但理毛反应在第10天进一步下降。相反，排便在第7天被抑制至0%，并在第10天完全恢复。运动活动明显受到抑制，在第二阶段精细运动比粗大运动减少得更多。多巴胺在第5天和第7天显著下降，但在第10天脑干中恢复了13%。去甲肾上腺素在大脑半球显著减少，而血清素在大脑半球和脑干中均减少。这两种胺类在第10天均未显示出显著恢复。大鼠大脑不同区域的旷场行为变化与多巴胺、去甲肾上腺素和血清素水平之间有趣的一致性值得注意，并已进行了讨论。
