Bigger C A, Tomaszewski J E, Dipple A, Lake R S
Science. 1980 Jul 25;209(4455):503-5. doi: 10.1126/science.6771871.
Important differences between the metabolic activation of 7,12-dimethylbenz[a]anthracene in intact cellular systems and in liver homogenates suggest that the use of homogenates in conjunction with short-term assays for carcinogens could yield misleading results.
在完整细胞系统和肝脏匀浆中,7,12-二甲基苯并[a]蒽的代谢活化存在重要差异,这表明将匀浆与致癌物短期检测方法结合使用可能会产生误导性结果。