蛋白质-能量缺乏大鼠体内[14C]苯甲酸的代谢归宿
The metabolic fate of [14C] benzoic acid in protein-energy deficient rats.
作者信息
Thabrew M I, Bababunmi E A, French M R
出版信息
Toxicol Lett. 1980 May;5(6):363-7. doi: 10.1016/0378-4274(80)90016-8.
The metabolic fate of [14C] benzoic acid administered i.p. to marasmic-kwashiorkor rats has been investigated. Rats fed a normal diet with benzoic acid administered i.p. at 200 mg/kg, excreted the benzoic acid mainly as hippuric acid (99% of 24 h excretion), while marasmic-kwashiorkor rats excreted 62--85% as hippuric acid and 14--37% as the glucuronide conjugate. 2 weeks after repletion metabolism of benzoic acid by the marasmic-kwashiorkor rats on the stock diet had returned to normal; most of the benzoate was excreted as hippuric acid.
已对腹腔注射[14C]苯甲酸的消瘦型夸希奥科病大鼠的代谢命运进行了研究。以200mg/kg的剂量腹腔注射苯甲酸的正常饮食大鼠，主要以马尿酸形式排泄苯甲酸（占24小时排泄量的99%），而消瘦型夸希奥科病大鼠则以马尿酸形式排泄62%-85%，以葡萄糖醛酸苷共轭物形式排泄14%-37%。恢复正常饮食2周后，消瘦型夸希奥科病大鼠对苯甲酸的代谢恢复正常；大部分苯甲酸盐以马尿酸形式排泄。
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