缺氧增强二氧化碳对脑血管的作用。

Enhancement of cerebrovascular effect of CO2 by hypoxia.

作者信息

Quint S R, Scremin O U, Sonnenschein R R, Rubinstein E H

出版信息

Stroke. 1980 May-Jun;11(3):286-9. doi: 10.1161/01.str.11.3.286.

DOI:10.1161/01.str.11.3.286

PMID:6771900

Abstract

Internal carotid blood flow, taken as an index of cerebral blood flow (CBF); arterial pressure; and respiratory O2 and CO2 concentrations, were measured in halothane (1%)-anesthetized, paralyzed and mechanically ventilated rabbits. CBF was determined at end-tidal CO2 of 4% (normocapnia) and 8%, as inspired O2 [O2]I) was varied stepwise over the range of 6.5 to 92%. Normocapnic CBF was constant over the range of 15 to 92% [O2]I, but it increased significantly to 240% and 380% of control when [O2]I was at 10% and 6.5%, respectively. Cerebrovascular response to CO2 was constant over the range of [O2]I tested, except for a significant elevation to 180% of control at [O2]I of 10%.

摘要

以颈内动脉血流作为脑血流量（CBF）的指标；测量了在氟烷（1%）麻醉、麻痹并机械通气的家兔中的动脉血压以及呼吸时的氧气和二氧化碳浓度。在呼气末二氧化碳为4%（正常碳酸血症）和8%时测定CBF，同时将吸入氧气浓度[O₂]I在6.5%至92%的范围内逐步变化。在15%至92%的[O₂]I范围内，正常碳酸血症时的CBF保持恒定，但当[O₂]I分别为10%和6.5%时，CBF显著增加至对照值的240%和380%。在测试的[O₂]I范围内，脑血管对二氧化碳的反应保持恒定，只是在[O₂]I为10%时显著升高至对照值的180%。