Hasegawa M, Tatsuno M, Houdou S, Takashima S, Okuyama K
Division of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, Tokyo, Japan.
Brain Dev. 1991 Nov;13(6):433-7. doi: 10.1016/s0387-7604(12)80043-x.
Cerebral blood flow velocity (CBFV) in the basilar artery, monitored by Doppler sonography, and cerebral blood flow (CBF) in the parietal cortex, monitored by Laser Doppler flowmetry, were continuously recorded and compared during and after hypoxic loading with nitrogen (N2) or carbon dioxide (CO2). On severe hypoxic loading (10% O2) of N2, CBFV and CBF increased with an increase in blood pressure (BP). On the other hand, with 18% and 15% O2 with CO2, CBFV and CBF increased with BP. However, there was a difference between CBF and CBFV in the recovery stage. CBF continued to be elevated for a long time, while CBFV rapidly normalized after loading. With 10% O2 with CO2, CBFV, CBF and BP decreased at first, and then increased during loading. Also, the difference between CBF and CBFV in the recovery stage being more definite. Thus, on continuous measurement, CBFV shows similar changes to CBF in response to hypoxia. However, CBFV shows different changes from CBF in association with dilatation or constriction of cerebral vessels. Resistance index (RI) shows different changes and have a different significance from CBF and CBFV.
采用多普勒超声监测基底动脉的脑血流速度（CBFV），并采用激光多普勒血流仪监测顶叶皮质的脑血流量（CBF），在氮气（N₂）或二氧化碳（CO₂）低氧负荷期间及之后持续记录并比较二者。在N₂严重低氧负荷（10% O₂）时，CBFV和CBF随血压（BP）升高而增加。另一方面，在18%和15% O₂加CO₂的情况下，CBFV和CBF随BP升高而增加。然而，在恢复阶段CBF和CBFV之间存在差异。CBF长时间持续升高，而CBFV在负荷后迅速恢复正常。在10% O₂加CO₂时，CBFV、CBF和BP起初下降，然后在负荷期间升高。此外，在恢复阶段CBF和CBFV之间的差异更明显。因此，连续测量时，CBFV在低氧反应中与CBF表现出相似变化。然而，与脑血管扩张或收缩相关时，CBFV与CBF表现出不同变化。阻力指数（RI）表现出不同变化，与CBF和CBFV具有不同意义。
