孕妇红细胞中的儿茶酚-O-甲基转移酶活性

Catechol-O-methyltransferase activity in erythrocytes of pregnant women.

作者信息

Bates G W, Edman C D, Porter J C, MacDonald P C

出版信息

Am J Obstet Gynecol. 1978 Jul 1;131(5):555-7. doi: 10.1016/0002-9378(78)90118-7.

Abstract

Catechol-O-methyltransferase (COMT) is the enzyme that converts catechols, e.g., catecholamines and catechol estrogens, to their methyl ethers. COMT activity measured in erythrocytes (RBC's) of healthy men (No. = 47) and healthy nonpregnant women (No. = 53) was 8.2 +4- 0.17 nmoles X ml.-1 (mean and standard error). The COMT activity in RBC's of healthy pregnant women (No. = 100) was 10.7 +/- 0.29 nmoles X ml.-1 RBC X hr.-1, a value which is significantly higher than that found in RBC's of men and nonpregnant women (p less than 0.001).

摘要

儿茶酚-O-甲基转移酶（COMT）是一种将儿茶酚（如儿茶酚胺和儿茶酚雌激素）转化为其甲基醚的酶。对47名健康男性和53名健康未孕女性红细胞（RBC）中COMT活性的检测结果为8.2±0.17纳摩尔·毫升⁻¹（平均值和标准误差）。100名健康孕妇红细胞中COMT活性为10.7±0.29纳摩尔·毫升⁻¹红细胞·小时⁻¹，该值显著高于男性和未孕女性红细胞中的值（p<0.001）。