Shields M B, Campbell D G, Simmons R J
Am J Ophthalmol. 1978 Jun;85(6):749-59. doi: 10.1016/s0002-9394(14)78101-2.
We studied 82 cases of essential iris atrophy. The findings support some traditional concepts of this complex spectrum of disorders, but conflict with others. Corneal abnormality appeared early and may be the primary disorder. A corneal endothelial disturbance was present in 55% of cases and corneal edema was present in 50%. Peripheral anterior synechiae occurred in all but one of the cases studied by gonioscopy. The pupil was distorted in 71% of the cases and was usually pulled in the direction of the most prominent synechia. The iris was stretched with stromal atrophy in 71%. Iris holes occurred in 33%. The degree of corneal and iris changes occurred as a spectrum of disorders. The prognosis for most patients with essential iris atrophy is slow progression with eventual involvement of vision because of corneal edema, secondary glaucoma, or both. Treatment of increased IOP was required in 77% of our cases, and 44% required surgical intervention.
我们研究了82例原发性虹膜萎缩病例。研究结果支持了关于这一复杂病症谱的一些传统观念，但也与其他观念存在冲突。角膜异常出现较早，可能是原发性病症。55%的病例存在角膜内皮紊乱，50%存在角膜水肿。在所有接受前房角镜检查的病例中，除1例外均发生周边前粘连。71%的病例瞳孔变形，通常向最明显的粘连方向牵拉。71%的病例虹膜因基质萎缩而伸展。33%的病例出现虹膜孔。角膜和虹膜变化的程度呈现为一系列病症。大多数原发性虹膜萎缩患者的预后是病情缓慢进展，最终因角膜水肿、继发性青光眼或两者兼而有之而累及视力。我们77%的病例需要治疗眼压升高，44%的病例需要手术干预。
