Wittebol-Post D, van Bijsterveld O P
Ophthalmologica. 1979;178(6):303-10. doi: 10.1159/000308841.
Chandler's syndrome and essential progressive iris atrophy, we believe, are two entities of the same syndrome. We have presented a case which could be considered a perfect intermediate. The mechanical 'stretch' theory of Campbell et al., supported to an extent by the light and electron microscopic findings of Rodrigues et al., is untenable in view of the observation in our patient that the first, and broad, peripheral anterior synechia was opposite the position of the displacement of the pupil. Every case in which corneal abnormality, glaucoma and iris changes are found, should be checked explicitly, with specular microscopy and gonioscopy, for corneal endothelial changes and in order to locate the area of predilection of peripheral anterior synechiae.
我们认为，钱德勒综合征和原发性进行性虹膜萎缩是同一综合征的两种类型。我们报告了一个可被视为完美中间类型的病例。坎贝尔等人的机械“拉伸”理论，在一定程度上得到了罗德里格斯等人光镜和电镜检查结果的支持，但鉴于我们患者的观察结果，即最初出现的广泛周边前粘连与瞳孔移位的位置相对，该理论难以成立。对于每一例发现有角膜异常、青光眼和虹膜改变的病例，都应通过镜面显微镜检查和前房角镜检查明确检查角膜内皮变化，并确定周边前粘连的好发部位。
