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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Vaartjes W J, den Breejen J N, Geelen M J, van den Bergh S G

Biochim Biophys Acta. 1980 Aug 5;592(1):28-37. doi: 10.1016/0005-2728(80)90111-5.

Preincubation of isolated rat-liver mitochondria in the presence of adenine nucleotides or Ca2+ results in definite and persistent changes in the initial rate of pyruvate transport. 2. These changes in the rate of pyruvate transport are accompanied by equally persistent changes in the opposite direction of the activity of pyruvate dehydrogenase (EC 1.2.4.1). 3. Changes of the transmembrane pH gradient and of the membrane potential, brought about by the pretreatments of the mitochondria, cannot account for the observed changes in the rate of pyruvate transport. 4. It is proposed that the pretreatment of the mitochondria directly modulates the activity of the mitochondrial pyruvate carrier. The possible regulatory role of such a modulation system is discussed.

在腺嘌呤核苷酸或Ca2+存在的情况下，对分离的大鼠肝脏线粒体进行预孵育，会导致丙酮酸转运初始速率发生明确且持久的变化。2. 丙酮酸转运速率的这些变化伴随着丙酮酸脱氢酶（EC 1.2.4.1）活性在相反方向上同样持久的变化。3. 线粒体预处理引起的跨膜pH梯度和膜电位变化，无法解释观察到的丙酮酸转运速率变化。4. 有人提出，线粒体的预处理直接调节线粒体丙酮酸载体的活性。讨论了这种调节系统可能的调节作用。

Vaartjes W J, den Breejen J N, Geelen M J, van den Bergh S G

Biochim Biophys Acta. 1980 Aug 5;592(1):28-37. doi: 10.1016/0005-2728(80)90111-5.

Preincubation of isolated rat-liver mitochondria in the presence of adenine nucleotides or Ca2+ results in definite and persistent changes in the initial rate of pyruvate transport. 2. These changes in the rate of pyruvate transport are accompanied by equally persistent changes in the opposite direction of the activity of pyruvate dehydrogenase (EC 1.2.4.1). 3. Changes of the transmembrane pH gradient and of the membrane potential, brought about by the pretreatments of the mitochondria, cannot account for the observed changes in the rate of pyruvate transport. 4. It is proposed that the pretreatment of the mitochondria directly modulates the activity of the mitochondrial pyruvate carrier. The possible regulatory role of such a modulation system is discussed.

在腺嘌呤核苷酸或Ca2+存在的情况下，对分离的大鼠肝脏线粒体进行预孵育，会导致丙酮酸转运初始速率发生明确且持久的变化。2. 丙酮酸转运速率的这些变化伴随着丙酮酸脱氢酶（EC 1.2.4.1）活性在相反方向上同样持久的变化。3. 线粒体预处理引起的跨膜pH梯度和膜电位变化，无法解释观察到的丙酮酸转运速率变化。4. 有人提出，线粒体的预处理直接调节线粒体丙酮酸载体的活性。讨论了这种调节系统可能的调节作用。