Horigane A, Horiguchi M, Matsumoto T
Biochim Biophys Acta. 1980 Jun 23;618(3):383-8.
Incubation of 2-amino-3-phosphono[3-14C]propionic acid with cell-free preparations of Tetrahymena pyriformis resulted in incorporation of the radioactivity into phosphoenolpyruvate. No radioactivity was incorporated into phosphoenolpyruvate and 2-phosphonoacetate. Thus, the catabolic pathway of 2-amino-3-phosphonopropionic acid in Tetrahymena appears to be the same route as that found in rats through deamination to produce 3-phosphonopyruvate which is converted to 2-phosphonoacetaldehyde by decarboxylation, followed by both dephosphonylation and amination of the aldehyde to give acetaldehyde and 2-aminoethylphosphonic acid, respectively.
将2-氨基-3-膦酰基[3-¹⁴C]丙酸与梨形四膜虫的无细胞制剂一起温育，导致放射性物质掺入磷酸烯醇丙酮酸中。磷酸烯醇丙酮酸和2-膦酰基乙酸中未掺入放射性。因此，梨形四膜虫中2-氨基-3-膦酰基丙酸的分解代谢途径似乎与在大鼠中发现的途径相同，即通过脱氨基产生3-膦酰基丙酮酸，然后通过脱羧转化为2-膦酰基乙醛，接着醛进行脱膦酰化和胺化反应，分别生成乙醛和2-氨基乙基膦酸。
