在经L-谷氨酸单钠（MSG）处理的大鼠中，性腺切除术后促黄体生成素/促卵泡激素（LH/FSH）升高延迟，甲状腺切除术后血清促甲状腺激素（TSH）升高延迟。

A delayed LH/FSH rise after gonadectomy and a delayed serum TSH rise after thyroidectomy in monosodium-L-glutamate (MSG)-treated rats.

作者信息

Greeley G H, Nicholson G F, Kizer J S

出版信息

Brain Res. 1980 Aug 11;195(1):111-22. doi: 10.1016/0006-8993(80)90870-7.

Abstract

The serum LH and FSH rise after gonadectomy and the serum TSH rise after thyroidectomy were examined in rats that received monosodium-L-glutamate (MSG) as neonates. The rise in serum gonadotrophins after gonadectomy was significantly delayed in both adult and peripubertal MSG-treated rats when compared to control castrates. Serum LH and FSH levels, however, eventually achieved levels in MSG-treated rats that were not significantly different than those of controls. The serum TSH rise after thyroidectomy was significantly delayed in adult female MSG-treated rats, but not in prepubertal female MSG-treated rats. Pituitary responsiveness to both exogenous LH-RH and TRH was unaffected by neonatal MSG treatment, with one exception: pituitary responsiveness to HL-RH of orchidectomized peripubertal males was blunted significantly. The results are discussed in terms of the possible neurotoxic effects of neonatal MSG treatment, as well as the altered hypothalamic sensitivity to gonadal steroids.

摘要

在新生期接受L-谷氨酸单钠（MSG）处理的大鼠中，检测了性腺切除术后血清促黄体生成素（LH）和促卵泡生成素（FSH）的升高以及甲状腺切除术后血清促甲状腺激素（TSH）的升高情况。与对照去势大鼠相比，成年和青春期前接受MSG处理的大鼠在性腺切除术后血清促性腺激素的升高明显延迟。然而，MSG处理大鼠的血清LH和FSH水平最终达到了与对照组无显著差异的水平。成年雌性MSG处理大鼠在甲状腺切除术后血清TSH的升高明显延迟，但青春期前雌性MSG处理大鼠则没有。垂体对外源性促性腺激素释放激素（LH-RH）和促甲状腺激素释放激素（TRH）的反应性不受新生期MSG处理的影响，但有一个例外：青春期前雄性去势大鼠对LH-RH的垂体反应性明显减弱。本文根据新生期MSG处理可能的神经毒性作用以及下丘脑对性腺类固醇敏感性的改变对结果进行了讨论。