Nemeroff C B, Lamartiniere C A, Mason G A, Squibb R E, Hong J S, Bondy S C
Neuroendocrinology. 1981 Nov;33(5):265-7. doi: 10.1159/000123243.
Serum levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin, estradiol-17 beta and testosterone were determined in adult rats that were treated in the neonatal period with monosodium L-glutamate (MSG) which has previously been shown to reliably produce destruction of arcuate nucleus perikarya. MSG-treated males had significantly smaller accessory sexual organs (seminal vesicles and ventral prostate) and tests and had significantly lower serum concentrations of FSH and testosterone than sex-matched controls. MSG-treated females had significantly lower serum concentrations of LH, FSH and estradiol-17 beta. Prolactin levels of MSG-treated rats were no different than sex-matched controls. This marked reduction in gonadal steroid levels (decreases 68%) and inappropriately low gonadotropin levels further characterizes the deficit of feedback regulation in the hypothalamic-pituitary-gonadal axis in MSG-treated rats.
在新生期用L-谷氨酸单钠（MSG）处理的成年大鼠中测定了血清促黄体生成素（LH）、促卵泡激素（FSH）、催乳素、雌二醇-17β和睾酮水平，此前已证明MSG能可靠地导致弓状核周体的破坏。经MSG处理的雄性大鼠的附属生殖器官（精囊和腹侧前列腺）和睾丸明显较小，且血清FSH和睾酮浓度明显低于性别匹配的对照组。经MSG处理的雌性大鼠的血清LH、FSH和雌二醇-17β浓度明显较低。经MSG处理的大鼠的催乳素水平与性别匹配的对照组无差异。性腺类固醇水平的显著降低（降低68%）和促性腺激素水平的异常降低进一步说明了经MSG处理的大鼠下丘脑-垂体-性腺轴反馈调节的缺陷。
