Töllner D, Hagemann G
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1977;88(3):303-10. doi: 10.1007/BF00305367.
The cell damage of the cytostatics Bleomycin and ICRF 159 were studied experimentally by the use of the following parameters: colony survival, colony-size-spectrometry and multiplicity of CHO-Fibroblasts. Series of increasing drug concentrations and simultaneous irradiation with 200 rds were measured. In the above mentioned tests an additive and no potentiating effect of damage by the cytostatics in combination with irradiation of 200 rds was found. Compared with Bleomycin, ICRF 159 showed a higher degree of damage to CHO-Fibroblasts.
通过使用以下参数对细胞抑制剂博来霉素和ICRF 159的细胞损伤进行了实验研究：集落存活、集落大小光谱测定和中国仓鼠卵巢成纤维细胞的增殖能力。测定了一系列递增的药物浓度以及同时进行200拉德的照射。在上述试验中，发现细胞抑制剂与200拉德照射联合使用时对损伤具有相加作用而非增效作用。与博来霉素相比，ICRF 159对中国仓鼠卵巢成纤维细胞的损伤程度更高。
