[Fragile site Xq27 and metabolism of monocarbons].
作者信息
Lejeune J
出版信息
C R Seances Acad Sci D. 1980 Apr 21;290(15):1075-7.
PMID:6772321
Abstract
After confirming the increase of the fragility of the site Xq27 by methotrexate and its decrease by 5-formyltetrahydrofolate, it is observed that L-serine, 5-amino-levulinate and L-4-hydroxy-proline at millimolar concentrations, reduce considerably the frequency of the anomaly in lymphocyte cultures. The possible relationships between this chromosomal marker, the one carbon cycle,and mental deficiency of the patients, are discussed.
摘要
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