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Absorption rate and bioavailability of valproic acid and its sodium from rectal dosage forms.

作者信息

Moolenaar F, Greving W J, Huizinga T

出版信息

Eur J Clin Pharmacol. 1980 Apr;17(4):309-15. doi: 10.1007/BF00625806.

DOI:10.1007/BF00625806
PMID:6772450
Abstract
摘要

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1
Absorption rate and bioavailability of valproic acid and its sodium from rectal dosage forms.
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Relative bioavailability, metabolism and tolerability of rectally administered oxcarbazepine suspension.直肠给药奥卡西平混悬液的相对生物利用度、代谢及耐受性
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本文引用的文献

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[Does medication by rectal route avoid the hepatic barrier?].经直肠给药能避开肝脏屏障吗？
Ann Pharm Fr. 1951 Sep-Oct;9(9-10):593-608.
2
Determination of lower fatty acids, particularly the anti-epileptic dipropyl-acetic acid, in biological materials by means of micro diffusion and gas chromatography.
Clin Chim Acta. 1973 Jan 24;43(2):215-22. doi: 10.1016/0009-8981(73)90454-3.
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Concentration of dipropylacetate in plasma.
Epilepsia. 1975 Nov;16(4):609-15. doi: 10.1111/j.1528-1157.1975.tb04743.x.
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Rectal drug administration: clinical pharmacokinetic considerations.直肠给药：临床药代动力学考量
Clin Pharmacokinet. 1982 Jul-Aug;7(4):285-311. doi: 10.2165/00003088-198207040-00002.
5
Clinical pharmacokinetics of valproic acid--1988.丙戊酸的临床药代动力学——1988年
Clin Pharmacokinet. 1988 Dec;15(6):367-89. doi: 10.2165/00003088-198815060-00002.
6
Bioavailability of sodium valproate suppositories during repeated administration at steady state in epileptic children.
Eur J Pediatr. 1987 Jul;146(4):404-7. doi: 10.1007/BF00444949.
7
Pharmacokinetics of rectal drug administration, Part II. Clinical applications of peripherally acting drugs, and conclusions.直肠给药的药代动力学，第二部分。外周作用药物的临床应用及结论。
Clin Pharmacokinet. 1991 Aug;21(2):110-28. doi: 10.2165/00003088-199121020-00003.
Sodium di-N-propylacetate (DPA) in the treatment of epilepsy. A review.二正丙基乙酸钠（DPA）治疗癫痫：综述
Epilepsia. 1975 Nov;16(4):549-73. doi: 10.1111/j.1528-1157.1975.tb04738.x.
5
Pharmacokinetics of di-n-propylacetate in epileptic patients.癫痫患者中丙二酸二正丙酯的药代动力学
Eur J Clin Pharmacol. 1975 Feb 28;8(2):97-105. doi: 10.1007/BF00561557.
6
Rapid determination of 4-hydroxybutyric acid (Gamma OH) and 2-propyl pentanoate (Depakine) in human plasma be means of gas-liquid chromatography.通过气液色谱法快速测定人血浆中的4-羟基丁酸（γ-羟基丁酸）和2-丙基戊酸（德巴金）。
J Chromatogr. 1976 Jun 9;121(1):150-2. doi: 10.1016/s0021-9673(00)82317-1.
7
Sodium valproate: a review of its pharmacological properties and therapeutic efficacy in epilepsy.丙戊酸钠：其药理学特性及在癫痫治疗中的疗效综述
Drugs. 1977 Feb;13(2):81-123. doi: 10.2165/00003495-197713020-00001.
8
Rectal administration of sodium valproate in status epilepticus.癫痫持续状态时直肠给予丙戊酸钠。
Neurology. 1978 Sep;28(9 Pt 1):897-9. doi: 10.1212/wnl.28.9.897.
9
Steady-state kinetics of valproic acid in epileptic patients.丙戊酸在癫痫患者中的稳态动力学
Clin Pharmacol Ther. 1978 Sep;24(3):324-32. doi: 10.1002/cpt1978243324.
10
Disposition of valproic acid in man.丙戊酸在人体内的处置。
Eur J Clin Pharmacol. 1977 Oct 14;12(2):125-32. doi: 10.1007/BF00645133.