Bruni J, Wilder B J, Willmore L J, Perchalski R J, Villarreal H J
Clin Pharmacol Ther. 1978 Sep;24(3):324-32. doi: 10.1002/cpt1978243324.
Pharmacokinetic evaluation and prediction were carried out in 20 epileptic patients. Using conventional pharmacokinetic techniques and a one-compartment model, predicted and observed valproic acid plasma concentrations were compared. Valproic acid assay was performed by gas-liquid chromatography. There was good agreement between predicted and observed plasma concentrations. Most patients had predicted half-lives (t1/2s) of 6 to 8 hr, independent of the plasma concentration of valproic acid. Five patients had predicted t1/2s of 12 hr. The correlation between dose and plasma level was poor. Most patients had valproic acid plasma levels between 55 and 100 microgram/ml. Administration of valproic acid three times a day with determination of individual plasma concentrations offers a reliable method of monitoring. Constant levels are maintained in individual patients, but there is substantial intersubject variation.
对20例癫痫患者进行了药代动力学评估和预测。采用传统药代动力学技术和一室模型，比较了丙戊酸血浆浓度的预测值和实测值。丙戊酸测定采用气液色谱法。预测血浆浓度与实测血浆浓度之间具有良好的一致性。大多数患者预测的半衰期（t1/2）为6至8小时，与丙戊酸血浆浓度无关。5例患者预测的t1/2为12小时。剂量与血浆水平之间的相关性较差。大多数患者的丙戊酸血浆水平在55至100微克/毫升之间。每日三次给予丙戊酸并测定个体血浆浓度提供了一种可靠的监测方法。个体患者体内可维持恒定水平，但个体间存在显著差异。
