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标准化实验动物及其需求。为何是非人灵长类动物?

Standardized laboratory animals their need. Why the nonhuman primate?

作者信息

Kalter S S

出版信息

Dev Biol Stand. 1980;45:3-11.

PMID:6772508
Abstract

It is apparent that the need for laboratory animals will continue. In most instances, those currently in use have been standardized by the facility providing these species. The major exception is the nonhuman primate which comes to investigtors almost directly from its natural environment with a minimum of conditioning. Because of its close phylogenetic relationship to man, nonhuman primates have been used in increasing numbers in research programs. Therefore, an international effort must be made to provide guidelines for standardization. The suggestion has been made that WHO provide leadership in developing: 1) breeding programs in countries of origin as well as user countries for desired species, and 2) specific information that will provide the required mechanisms for establishing a standardilzed simian.

摘要

显然,对实验动物的需求仍将持续。在大多数情况下,目前所使用的实验动物已由提供这些物种的机构进行了标准化。主要的例外是非人类灵长类动物,它们几乎是直接从自然环境来到研究者手中,经过的驯化极少。由于其与人类在系统发育上关系密切,非人类灵长类动物在研究项目中的使用数量一直在增加。因此,必须做出国际努力来提供标准化指南。有人建议世界卫生组织在制定以下方面发挥领导作用:1)在原产国以及使用国开展针对所需物种的繁殖计划,以及2)提供具体信息,以便为建立标准化的猿猴提供所需机制。

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