Urbaschek R, Urbaschek B
Klin Wochenschr. 1982 Jul 15;60(14):746-8. doi: 10.1007/BF01716569.
The status of hyperreactivity and hyporeactivity following the administration of endotoxin in a susceptible host represents phenomena which are of interest in an attempt to understand the role of endotoxins in pathophysiological events in general. Two experimental approaches designed to examine these events are reported herein; i.v. injection with minute concentrations of endotoxin (10 ng of a BOIVIN endotoxin from E. coli 0111) induces tolerance against lethal doses of endotoxin (0.5 microgram or 5.0 microgram) within 24 h in hyperreactive NMRI mice that were infected 14 days before with BCG. Transfer of post-endotoxin serum from BCG infected mice, which contains a myriad of macrophage mediators and which induces nonspecific resistance to X-irradiation, renders a strain of mice (C3H/HeJ) that is hyporeactive to endotoxins, susceptible to the lethal effect of endotoxin. Studies of the role of the macrophage and its mediators in the experimental models described here may contribute to a further understanding of the mechanisms underlying endotoxin-induced biological activities.
在内毒素敏感宿主中，注射内毒素后出现的高反应性和低反应性状态是普遍理解内毒素在病理生理事件中作用时令人感兴趣的现象。本文报道了两种旨在研究这些事件的实验方法；静脉注射微量浓度的内毒素（10纳克来自大肠杆菌0111的博伊文内毒素）可在24小时内使14天前感染卡介苗的高反应性NMRI小鼠对致死剂量的内毒素（0.5微克或5.0微克）产生耐受性。来自卡介苗感染小鼠的内毒素后血清转移，其中含有大量巨噬细胞介质并能诱导对X射线的非特异性抗性，使对内毒素低反应性的小鼠品系（C3H/HeJ）对内毒素的致死作用敏感。在此描述的实验模型中对巨噬细胞及其介质作用的研究可能有助于进一步理解内毒素诱导生物活性的潜在机制。
