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猕猴齿状核和间位核小脑上行投射的拓扑组织:顺行变性研究

Topographical organization of ascending cerebellar projections from the dentate and interposed nuclei in Macaca mulatta: an anterograde degeneration study.

作者信息

Stanton G B

出版信息

J Comp Neurol. 1980 Apr 15;190(4):699-731. doi: 10.1002/cne.901900406.

DOI:10.1002/cne.901900406
PMID:6772694
Abstract

Discrete electrolytic lesions were placed in the dentate and interpositus cerebellar nuclei in th monkey Macaca mulatta and anterograde degeneration was traced in the ascending limb of the brachium conjunctivum using the Wiitanen technique. The dentate and interpositus anterior (IA) nuclei project topographically onto the two somatotopically organized divisions of the red nucleus and the ventrolateral-ventral intermediate nuclei of the thalamus (VL-Vim). Caudal parts of the dentate project to face areas in medial parts of the parvocellular red nucleus (RNpc) and VL-Vim, rostrolateral parts to central arm areas in these nuclei. There is a small projection from the rostroventral dentate to lateral hindlimb areas in RNpc and VL. Dorsal parts of the dentate project to ventral parts of RNpc and VLc-Vim (distal limb musculature area) exclusively, whereas ventral parts of the dentate project to dorsal parts of RNpc with some overlap ventrally dorsomedial VLc (proximal limb musculature and premotor areas). Caudal parts of IA project to medial forelimb and rostral parts to lateral hindlimb areas in the magnocellular red nucleus (RNmc) and VL-Vim. Projections from IA are greatest to distal musculature areas in VL-Vim. No projections from the interpositus posterior nucleus (IP) to the red nucleus could be identified positively, but projections to VL-Vim are to proximal hindlimb musculature and premotor areas.

摘要

在恒河猴(猕猴)的齿状核和小脑间位核中制作离散性电解损伤,并采用维塔宁技术追踪结合臂升支中的顺行性变性。齿状核和间位核前部(IA)在地形上投射到红核以及丘脑腹外侧 - 腹中间核(VL - Vim)的两个按躯体定位组织的分区。齿状核的尾部投射到小细胞红核(RNpc)内侧部分和VL - Vim的面部区域,嘴侧外侧部分投射到这些核的中央臂区域。齿状核嘴腹侧有一小部分投射到RNpc和VL的外侧后肢区域。齿状核的背侧部分专门投射到RNpc的腹侧部分和VLc - Vim(远端肢体肌肉组织区域),而齿状核的腹侧部分投射到RNpc的背侧部分,在腹侧与背内侧VLc(近端肢体肌肉组织和运动前区)有一些重叠。IA的尾部投射到巨细胞红核(RNmc)的内侧前肢区域和嘴侧部分投射到外侧后肢区域以及VL - Vim。IA向VL - Vim的远端肌肉组织区域的投射最强。未明确鉴定到间位后核(IP)向红核有投射,但向VL - Vim的投射是到近端后肢肌肉组织和运动前区。

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