Alper R H, Demarest K T, Moore K E
J Neural Transm. 1980;48(3):157-65. doi: 10.1007/BF01243500.
On the basis of biochemical indices of dopamine (DA) nerve activity (decline of DA after inhibition of tyrosine hydroxylase, accumulation of DOPA after inhibition of DOPA decarboxylase) it was revealed that morphine increases the activity of nigrostriatal and mesolimbic DA nerves which terminate in the striatum, nucleus accumbens and olfactory tubercle, but reduce the activity of tuberoinfundibular DA nerves which terminate in the median eminence. Morphine had no effect on tuberohypophyseal DA nerves which project to the posterior pituitary. Naloxone was without effect per se, but blocked the effects of morphine on DOPA accumulation. Thus, morphine differentially alters the diverse DA neuronal systems in the rat brain.
基于多巴胺（DA）神经活动的生化指标（酪氨酸羟化酶抑制后DA减少，多巴脱羧酶抑制后多巴积累）发现，吗啡可增加终止于纹状体、伏隔核和嗅结节的黑质纹状体及中脑边缘DA神经的活性，但会降低终止于正中隆起的结节漏斗DA神经的活性。吗啡对投射到垂体后叶的结节垂体DA神经没有影响。纳洛酮本身无作用，但可阻断吗啡对多巴积累的影响。因此，吗啡对大鼠脑中不同的DA神经元系统有不同的影响。
