Alper R H, Demarest K T, Moore K E
Neuroendocrinology. 1980 Aug;31(2):112-5. doi: 10.1159/000123060.
The concentration of dopamine (DA) and the accumulation of DOPA following the administration of a decarboxylase inhibitor were determined in the rat striatum, median eminence and posterior pituitary, regions containing terminals of nigrostriatal, tuberoinfundibular and tuberohypophyseal DA nerves, respectively. Severe dehydration (2 days water deprivation followed by 3 days of 2% NaCl substituted for drinking water) increased the concentration of DA in the posterior pituitary but not in the striatum or median eminence. Less severe dehydration caused by 2 or 3 days of water deprivation did not alter steady state concentrations of DA, but increased DOPA accumulation, an index of DA nerve activity, only in the posterior pituitary. Food deprivation for 3 days did not alter DOPA accumulation in the posterior pituitary. These results suggest that dehydration selectively activates the tuberohypophyseal DA neuronal system in the rat.
在大鼠纹状体、正中隆起和垂体后叶中测定了给予脱羧酶抑制剂后多巴胺（DA）的浓度和多巴的蓄积情况，这些区域分别含有黑质纹状体、结节漏斗和结节垂体DA神经的终末。严重脱水（2天禁水，随后3天用2%氯化钠替代饮用水）使垂体后叶中DA的浓度升高，但纹状体或正中隆起中的DA浓度未升高。由2天或3天禁水引起的不太严重的脱水并未改变DA的稳态浓度，但仅使垂体后叶中作为DA神经活动指标的多巴蓄积增加。3天禁食并未改变垂体后叶中多巴的蓄积。这些结果表明，脱水可选择性激活大鼠的结节垂体DA神经元系统。
