血液pH值对远端肾单位氢离子分泌的影响。

Effect of blood pH on distal nephron hydrogen ion secretion.

作者信息

Gougoux A, Vinay P, Lemieux G, Richardson R M, Tam S, Goldstein M B, Stinebaugh B J, Halperin M L

出版信息

Kidney Int. 1980 May;17(5):615-21. doi: 10.1038/ki.1980.72.

DOI:10.1038/ki.1980.72

Abstract

The purpose o this study was to determine the effect of changes in blood hydrogen ion concentrations on urine acidification. The urine minus the blood PCO2 gradient in alkaline urine was used to monitor distal nephron hydrogen ion secretion. To obtain alkaline urine during acidemia, we induced proximal renal tubular acidosis by lysine. The urine minus the blood PCO2 gradient was evaluated relative to the urine bicarbonate concentration over a range of blood pH values. For any given urine bicarbonate concentration, the urine minus the blood PCO2 gradient was directly related to the blood hydrogen ion concentration. Conclusions. Acidemia stimulates and alkalemia inhibits distal nephron hydrogen ion secretion. Because the slope relating the urine minus the blood PCO2 gradient to the urine bicarbonate concentration was much steeper in urine from acidemic dogs, this change in relationship cannot be explained by a simple chemical equilibrium of the bicarbonate buffer system.

摘要

本研究的目的是确定血液氢离子浓度变化对尿液酸化的影响。碱性尿液中尿与血二氧化碳分压梯度用于监测远端肾单位氢离子分泌。为了在酸血症期间获得碱性尿液，我们用赖氨酸诱导近端肾小管酸中毒。在一系列血液pH值范围内，相对于尿碳酸氢盐浓度评估尿与血二氧化碳分压梯度。对于任何给定的尿碳酸氢盐浓度，尿与血二氧化碳分压梯度与血液氢离子浓度直接相关。结论。酸血症刺激而碱血症抑制远端肾单位氢离子分泌。由于酸血症犬尿液中尿与血二氧化碳分压梯度与尿碳酸氢盐浓度之间的斜率要陡得多，这种关系的变化不能用碳酸氢盐缓冲系统的简单化学平衡来解释。