Williams P C, Stern M D, Bowen P D, Brooks R A, Hammock M K, Bowman R L, Di Chiro G
Med Res Eng. 1980;13(2):3-5.
We have demonstrated the feasibility of using laser doppler spectroscopy to map regional blood flow distribution on the surface of the cerebral cortex. Rhesus monkeys underwent craniotomy, with replacement of part of the calvarium by a transparent plastic dome. A stroke was produced on one side by ligation of the middle cerebral artery. A flow index was computed from a weighted bandwidth of the doppler spectrum of helium-neon laser light scattered from the surface of the cortex, the doppler shift being due to scattering from moving blood cells in the microcirculation. By measuring the doppler flow index at a grid of points over the surface, the region of the stroke was easily delineated, and its progression with time observed. The method provides a rapid measurement with a spatial resolution of about 1 mm.
我们已经证明了使用激光多普勒光谱法绘制大脑皮质表面区域血流分布的可行性。恒河猴接受了开颅手术，部分颅骨被一个透明塑料穹顶所取代。通过结扎大脑中动脉在一侧制造中风。血流指数是根据从皮质表面散射的氦氖激光的多普勒光谱的加权带宽计算得出的，多普勒频移是由于微循环中移动血细胞的散射所致。通过在皮质表面的网格点测量多普勒血流指数，中风区域很容易被描绘出来，并观察到其随时间的进展。该方法提供了一种空间分辨率约为1毫米的快速测量方法。
