Wang M, Kopple J D, Swendseid M E
Metabolism. 1980 Aug;29(8):773-6. doi: 10.1016/0026-0495(80)90202-4.
The metabolism of ornithine and putrescine was studied in vivo in chronically uremic and control rats. Rats were injected intraperitoneally with 1,4-14C-ornithine or 1,4-14C-putrescine and expired 14CO2 was collected for 4 hr. After injection of 1-14C-ornithine. 14CO2 expiration was decreased in uremic rats as compared to controls. Conversely, after 1,4-14C-putrescine injection, expiration of 14CO2 was increased in uremic rats as compared to controls. Four hours after the injection of 1-14C-ornithine, there was more radioactivity in liver and muscle and less radioactivity in kidney of uremic rats as compared to the respective sources in control rats. In uremic rats, 4 hr after 1,4-14C-putrescine injection, the radioactivity retained in the muscle and plasma was greater than in corresponding sources in control rats; whereas the radioactivity retained in uremic liver and kidney was similar to that of control rats. The greater putrescine-derived radioactivity retained in uremic tissues reflects either the retention of injection racer compounds, or retention or decreased catabolism of putrescine metabolites. From 14CO2 expiration data obtained, it appears that ornithine catabolism is reduced while putrescine catabolism is increased in uremia.
在慢性尿毒症大鼠和对照大鼠体内研究了鸟氨酸和腐胺的代谢。给大鼠腹腔注射1,4-¹⁴C-鸟氨酸或1,4-¹⁴C-腐胺，并收集4小时呼出的¹⁴CO₂。注射1-¹⁴C-鸟氨酸后，与对照相比，尿毒症大鼠的¹⁴CO₂呼出量减少。相反，注射1,4-¹⁴C-腐胺后，与对照相比，尿毒症大鼠的¹⁴CO₂呼出量增加。注射1-¹⁴C-鸟氨酸4小时后，与对照大鼠相应组织相比，尿毒症大鼠肝脏和肌肉中的放射性更多，肾脏中的放射性更少。在尿毒症大鼠中，注射1,4-¹⁴C-腐胺4小时后，肌肉和血浆中保留的放射性大于对照大鼠相应组织中的放射性；而尿毒症大鼠肝脏和肾脏中保留的放射性与对照大鼠相似。尿毒症组织中保留的源自腐胺的放射性增加，反映了注射的示踪化合物的潴留，或者腐胺代谢产物的潴留或分解代谢减少。从获得的¹⁴CO₂呼出数据来看，尿毒症时鸟氨酸分解代谢减少而腐胺分解代谢增加。
