Hutchinson P F, Harrison R N
Thorax. 1980 Nov;35(11):869-72. doi: 10.1136/thx.35.11.869.
The effect of beta-adrenoceptor antagonists on the respiratory response to carbon dioxide rebreathing was studied in eight normal subjects. Propranolol, atenolol, metoprolol, and placebo were given in random, double-blind fashion. Subjects were studied before each treatment period, after one dose, and after eight days of treatment with each drug. A rebreathing method was used to produce progressive hypercapnia and the respiratory response was assessed by measuring minute ventilation and maximum rate of change of inspiratory mouth pressure. Beta-blockade was assessed by the reduction in heart rate during steady state exercise on a cycle ergometer. There was no change in the respiratory response to carbon dioxide after a single dose or eight days treatment of any drug. All three active drugs produced a significant reduction in exercise heart rate. The forced expiratory volume in one second was not altered by any of the drugs.
在八名正常受试者中研究了β-肾上腺素能受体拮抗剂对二氧化碳再呼吸时呼吸反应的影响。普萘洛尔、阿替洛尔、美托洛尔和安慰剂以随机、双盲方式给药。在每个治疗期之前、一剂后以及每种药物治疗八天后对受试者进行研究。采用再呼吸方法产生渐进性高碳酸血症，并通过测量分钟通气量和吸气口压的最大变化率来评估呼吸反应。通过在自行车测力计上进行稳态运动时心率的降低来评估β受体阻滞情况。任何一种药物单次给药或治疗八天后，对二氧化碳的呼吸反应均无变化。所有三种活性药物均使运动心率显著降低。一秒用力呼气量未因任何一种药物而改变。
