Mitema E S, Oehme F W, Penumarthy L, Moore W E
Am J Vet Res. 1980 May;41(5):682-5.
The effect of chronic oral led acetate administration on canine bone marrow was studied. Two dogs (group 1) were used as controls, 4 dogs (group 2) were given 2 mg of lead/kg of body weight daily, and 4 dogs (group 3) were given 5 mg of lead/kg daily. After a 7-day stabilizaion period, lead dosing was conducted for 91 days (13 weeks), after which half of each group was treated with calcium ethylenediaminetetraacetic acid. All dogs were then observed for another 28 days (4 weeks). Blood lead values and bone marrow cellular changes were monitored once a week during the 126 days (18 weeks) of study. Lead-dosed dogs had lower weight gains than the controls. Clinical signs of toxicosis were observed after 6 weeks in one dog in group 3. Anorexia, body weight loss, CNS depression, muscular weakness, and trembling were seen. Blood lead concentrations increased in all group 2 and 3 dogs. Lead caused increases in bone marrow segmented neutrophils and myeloid series cells, and increased myeloid:erythroid ratios. Blood lead concentrations and myeloid:erythroid ratios decreased after cessation of lead administration.
研究了长期口服醋酸铅对犬骨髓的影响。两只狗（第1组）作为对照，4只狗（第2组）每天给予2毫克/千克体重的铅，4只狗（第3组）每天给予5毫克/千克体重的铅。经过7天的稳定期后，进行91天（13周）的铅给药，之后每组一半的狗用乙二胺四乙酸钙进行治疗。然后所有狗再观察28天（4周）。在研究的126天（18周）内，每周监测一次血铅值和骨髓细胞变化。服用铅的狗体重增加低于对照组。第3组的一只狗在6周后出现中毒临床症状。可见厌食、体重减轻、中枢神经系统抑制、肌肉无力和颤抖。第2组和第3组所有狗的血铅浓度均升高。铅导致骨髓分叶中性粒细胞和髓系细胞增加，髓系：红系比例升高。停止给予铅后，血铅浓度和髓系：红系比例下降。
