Schlick E, Friedberg K D
Arch Toxicol. 1982 Mar;49(3-4):227-36. doi: 10.1007/BF00347870.
The influence of lead on the number of nucleated bone marrow cells and pluripotent stem cells in femur bone marrow was investigated in mice. It was found that neither a single nor 10 days' oral administration of lead at doses of 10-1,000 micrograms PbAc/kg b.w. led to any change in the bone marrow cellularity. After 1 month's oral administration of 1,000 micrograms PbAc/kg b.w., on the other hand, there was a significant reduction of nucleated bone marrow cells and pluripotent stem cells in the femur bone marrow of up to 20% in comparison with controls. Within 14 days after completing the lead administration, however, normal values in the bone marrow cellularity were found again. Three months' oral administration of lead at doses of 100 and 1,000 micrograms PbAc/kg b.w. led to a significant reduction in nucleated bone marrow cells and pluripotent stem cells in the femur bone marrow of up to 28% compared with the controls. In contrast to the experiments with 1 month's oral administration of lead the regeneration of the bone marrow was not completed 14 days after completing the administration of the lead. These results show that lead at doses above 100 micrograms PbAc/kg b.w. causes on long-term administration a clear reduction of the nucleated bone marrow cells combined with a depressed regeneration ability of the pluripotent stem cells.
研究了铅对小鼠股骨骨髓中有核骨髓细胞和多能干细胞数量的影响。结果发现，以10 - 1000微克醋酸铅/千克体重的剂量单次或连续10天口服铅，均未导致骨髓细胞数量发生任何变化。另一方面，以1000微克醋酸铅/千克体重的剂量口服1个月后，与对照组相比，小鼠股骨骨髓中有核骨髓细胞和多能干细胞显著减少，降幅高达20%。然而，在停止给予铅后的14天内，骨髓细胞数量又恢复到了正常水平。以100和1000微克醋酸铅/千克体重的剂量口服铅3个月后，与对照组相比，小鼠股骨骨髓中有核骨髓细胞和多能干细胞显著减少，降幅高达28%。与口服铅1个月的实验不同，在停止给予铅14天后，骨髓并未恢复。这些结果表明，长期给予剂量高于100微克醋酸铅/千克体重的铅会导致有核骨髓细胞明显减少，同时多能干细胞的再生能力受到抑制。
