Sidi Y, Boer P, Pick I, Pinkhas J, Sperling O
Biomedicine. 1980 Apr;33(2):39-41.
The activity of adenosine deaminase (ADA) and of purine nucleoside phosphorylase (PNP) was determined in the peripheral lymphocytes of patients with diseases associated with acquired partial dysfunction of the immune response. Increase ADA activity was found in patients with Waldenstrom's macroglobulinemia and in some patients with non-Hodgkin's lymphoma. Increased PNP activity was found in patients with non Hodgkin's lymphoma whereas decreased PNP activity was fund in patients with connective tissue disorders. The alternations found in ADA and PNP activities probably reflect changes in the lymphocyte subpopulations and do not seem to have an etiological role in the pathogenesis of the disturbed immune response.
在患有与获得性部分免疫反应功能障碍相关疾病的患者外周淋巴细胞中，测定了腺苷脱氨酶（ADA）和嘌呤核苷磷酸化酶（PNP）的活性。在华氏巨球蛋白血症患者和一些非霍奇金淋巴瘤患者中发现ADA活性增加。在非霍奇金淋巴瘤患者中发现PNP活性增加，而在结缔组织疾病患者中发现PNP活性降低。ADA和PNP活性的变化可能反映了淋巴细胞亚群的变化，似乎在免疫反应紊乱的发病机制中没有病因学作用。
