Heath H
Endocrinology. 1980 Oct;107(4):977-81. doi: 10.1210/endo-107-4-977.
Recent in vitro and in vivo evidence shows that secretion of parathyroid hormone (PTH) and calcitonin (CT) is stimulated by beta-adrenergic agonists and inhibited by beta-adrenergic antagonists. To assess the possible roles of adrenal medullary or adrenergic nerve terminal catecholamines in calcium homeostasis, we have examined serum calcium (Ca), immunoreactive PTH (iPTH), and immunoreactive CT (iCT) in control, adrenalectomized (ADRX), and chemically sympathectomized [6-hydroxydopamine (6-OHDA)] rats. Animals were studied in the fed and fasted states, after ip injection of CA and after ip injection of EDTA. In comparison with fasted rats, fed control rats tended to have increased serum Ca and iCT, but decreased or unchanged iPTH. Neither adrenalectomy nor 6-OHDA treatment notably altered this pattern. Serum iCT concentrations rose markedly after ip Ca, and peak iCT responses remained normal in ADRX and 6-OHDA-treated rats. Similarly, rises of iPTH levels after EDTA-induced hypocalcemia were normal in ADRX and 6-OHDA-treated rats. The only possible abnormality concerned basal serum iCT levels after 6-OHDA treatment, which were lower than control in five of six experiments, albeit not always significantly. We conclude that deprivation of either adrenal medullary or adrenergic nerve terminal catecholamines does not interfere with plasma Ca regulation or the homeostatic responses of PTH and CT in the rat.
最近的体外和体内证据表明，β-肾上腺素能激动剂可刺激甲状旁腺激素（PTH）和降钙素（CT）的分泌，而β-肾上腺素能拮抗剂则抑制其分泌。为了评估肾上腺髓质或肾上腺素能神经末梢儿茶酚胺在钙稳态中的可能作用，我们检测了对照、肾上腺切除（ADRX）和化学性交感神经切除[6-羟基多巴胺（6-OHDA）]大鼠的血清钙（Ca）、免疫反应性PTH（iPTH）和免疫反应性CT（iCT）。在给动物腹腔注射CA和腹腔注射EDTA后，分别在进食和禁食状态下对其进行研究。与禁食大鼠相比，进食的对照大鼠血清Ca和iCT往往升高，但iPTH降低或不变。肾上腺切除术和6-OHDA治疗均未显著改变这种模式。腹腔注射钙后血清iCT浓度显著升高，ADRX和6-OHDA处理的大鼠iCT的峰值反应仍正常。同样，ADRX和6-OHDA处理的大鼠在EDTA诱导的低钙血症后iPTH水平的升高也正常。唯一可能的异常是6-OHDA治疗后基础血清iCT水平，在六个实验中有五个实验低于对照，尽管并不总是显著低于对照。我们得出结论，肾上腺髓质或肾上腺素能神经末梢儿茶酚胺的缺乏不会干扰大鼠血浆钙的调节以及PTH和CT的稳态反应。
