Joborn H, Hjemdahl P, Wide L, Akerström G, Ljunghall S
J Endocrinol Invest. 1987 Apr;10(2):153-6. doi: 10.1007/BF03347181.
The parathyroid glands contain sympathetic nerve endings and the parathyroid cells are endowed with beta-adrenergic receptors. The physiological role of the sympathoadrenal system for the secretion of parathyroid hormone (PTH) has, however, not been clarified. Using the technique of lower body negative pressure (LBNP), which is an established method to achieve sympathetic nerve activation, it was found in 17 healthy subjects that the venous serum levels of PTH were reduced by 7% within 20 min [from 0.79 +/- 0.12 (SD) to 0.74 +/- 0.11 arbU/l, p less than 0.01, paired t test]. The reduction corresponds to 30% of the maximal suppressibility of PTH by induced hypercalcemia or following parathyroidectomy when studied with the same PTH assay and with the short time period involved. After cessation of LBNP the PTH levels returned to baseline within 20 min. There were no concomitant changes of the plasma ionized calcium concentrations. The findings are compatible with a role for the sympathetic nervous system in the physiologic regulation of the secretion of PTH.
甲状旁腺含有交感神经末梢，甲状旁腺细胞具有β - 肾上腺素能受体。然而，交感肾上腺系统对甲状旁腺激素（PTH）分泌的生理作用尚未阐明。利用下体负压（LBNP）技术（这是一种已确立的实现交感神经激活的方法），在17名健康受试者中发现，在20分钟内PTH的静脉血清水平降低了7%[从0.79±0.12（标准差）降至0.74±0.11 arbU/l，p＜0.01，配对t检验]。当使用相同的PTH检测方法且在较短时间内进行研究时，这种降低相当于诱导性高钙血症或甲状旁腺切除术后PTH最大抑制率的30%。LBNP停止后，PTH水平在20分钟内恢复到基线。血浆离子钙浓度没有伴随变化。这些发现与交感神经系统在PTH分泌的生理调节中的作用相符。
