Bretzel R G, Schneider J, Dobroschke J, Schwemmle K, Pfeiffer E F, Federlin K
Horm Metab Res. 1980;12(6):274-5. doi: 10.1055/s-2007-996265.
Islet transplantation in human diabetes at present is confronted with two major obstacles: isolation of a sufficient number of islets and islet graft rejection. "Tissue banking" would enable islet pooling from various donors and offers furthermore the advantage of in vitro manipulations in order to reduce islet immunogenicity. Recently we have reported successful cryopreservation and subsequent transplantation of porcine islets (Bretzel, Beule, Schäfer, Schneider, Pfeiffer and Federlin 1979). These preliminary data deal with cryopreservation and transplantation of isolated rat islets and cryopreservation of isolated human islets.
目前，人类糖尿病的胰岛移植面临两大障碍：获取足够数量的胰岛以及胰岛移植排斥反应。“组织库”能够汇集来自不同供体的胰岛，并且还具有体外操作的优势，以降低胰岛的免疫原性。最近，我们报道了猪胰岛的成功冷冻保存及后续移植（布雷策尔、贝勒、舍费尔、施奈德、普费弗和费德林，1979年）。这些初步数据涉及分离的大鼠胰岛的冷冻保存与移植以及分离的人类胰岛的冷冻保存。
