胎羊的呼吸运动及高碳酸血症的影响。
Breathing movements in fetal lambs and the effect of hypercapnia.
作者信息
Chapman R L, Dawes G S, Rurak D W, Wilds P L
出版信息
J Physiol. 1980 May;302:19-29. doi: 10.1113/jphysiol.1980.sp013227.
Abstract
- A breath-by-breath analysis was made of tracheal pressure records from fetal lambs in utero at 117--130 days gestation. 2. Episodes of rapid irregular breathing were accompanied by diaphragmatic e.m.g. activity and were characterized by a gradual increase in breathing rate initially and a terminal decline. Within each episode breathing was very irregular. 3. Inspiratory time increased with increasing expiratory time rapidly as the rate fell to about 80/min, and thereafter more slowly. 4. The principal effects of hypercapnia (a rise in fetal Pa, CO2 by approximately 11 mmHg) were to increase the depth of fetal breathing, by nearly twofold, and to make breathing much more regular. A change in rate was doubtful because of the skew distribution of normal breath intervals.
摘要
- 对妊娠117 - 130天子宫内胎羊的气管压力记录进行逐次呼吸分析。2. 快速不规则呼吸发作伴有膈肌肌电图活动，其特征是最初呼吸频率逐渐增加，末期下降。在每次发作期间，呼吸非常不规则。3. 随着呼吸频率降至约80次/分钟，吸气时间随着呼气时间的增加而迅速增加，此后增加得更慢。4. 高碳酸血症（胎儿动脉血二氧化碳分压升高约11 mmHg）的主要影响是使胎儿呼吸深度增加近两倍，并使呼吸更加规律。由于正常呼吸间隔的偏态分布，呼吸频率的变化难以确定。
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