大鼠实验性尿毒症中的小肠二肽酶和双糖酶

Small intestinal dipeptidases and disaccharidases in experimental uremia in rats.

作者信息

Sterner G, Asp N G, Dahlqvist A, Denneberg T, Lindberg T

出版信息

Nephron. 1980;26(3):149-52. doi: 10.1159/000181971.

DOI:10.1159/000181971

Abstract

Rats were made severely uremic with partial nephrectomy (24-hour creatinine clearance 10% of normal). Jejunal dipeptidase activities (substrates: glycyl-L-leucine, L-alanyl-L-proline, and L-methionyl-L-methionine), disaccharidase activities (maltase, sucrase, trehalase, and lactase) and morphology were studied. A highly significant increase in glycyl-L-leucine and L-methionyl-L-methionine dipeptidases was found in uremic rats compared with controls. Proline dipeptidase activities were unaltered. Disaccharidase activities showed a slight increase in sucrase in uremic rats; otherwise no change was found.

摘要

通过部分肾切除术使大鼠严重尿毒症（24小时肌酐清除率为正常的10%）。研究了空肠二肽酶活性（底物：甘氨酰-L-亮氨酸、L-丙氨酰-L-脯氨酸和L-甲硫氨酰-L-甲硫氨酸）、双糖酶活性（麦芽糖酶、蔗糖酶、海藻糖酶和乳糖酶）及形态。与对照组相比，发现尿毒症大鼠的甘氨酰-L-亮氨酸和L-甲硫氨酰-L-甲硫氨酸二肽酶有极显著增加。脯氨酸二肽酶活性未改变。双糖酶活性方面，尿毒症大鼠的蔗糖酶有轻微增加；其他方面未发现变化。