1,25-二羟基维生素D3对尿毒症大鼠肠道双糖酶的影响

Effect of 1,25-dihydroxyvitamin D3 on intestinal disaccharidases in uremic rats.

作者信息

Inagaki O, Fujita Y, Inoue S, Mori H, Gomikawa S, Yorifuji R, Hirabayashi T

出版信息

Nephron. 1986;44(1):75-7. doi: 10.1159/000183916.

Abstract

The effect of 1,25-dihydroxyvitamin D3 (1,25-D) on the activity of intestinal disaccharidases, maltase, sucrase, trehalase and lactase, was studied in five-sixths nephrectomized uremic rats. In uremic rats, maltase, sucrase and trehalase activities were lower than in sham-operated rats. Administration of 1,25-D produced significant improvement of maltase, sucrase, trehalase and lactase activities in uremic rats. These results suggest that activities of intestinal disaccharidases are reduced in uremic rats and these activities are normalized after 1,25-D administration.

摘要

在五分之六肾切除的尿毒症大鼠中，研究了1,25 - 二羟维生素D3（1,25 - D）对肠道双糖酶、麦芽糖酶、蔗糖酶、海藻糖酶和乳糖酶活性的影响。在尿毒症大鼠中，麦芽糖酶、蔗糖酶和海藻糖酶的活性低于假手术大鼠。给予1,25 - D可使尿毒症大鼠的麦芽糖酶、蔗糖酶、海藻糖酶和乳糖酶活性显著改善。这些结果表明，尿毒症大鼠肠道双糖酶的活性降低，给予1,25 - D后这些活性恢复正常。