丙戊酸的代谢相互作用（作者译）
[Metabolic interaction of valproic acid (author's transl)].
作者信息
Borchert H H, Schuster S, Pfeifer S
出版信息
Pharmazie. 1980;34(5-6):313-4.
PMID:6774345
Abstract
Valproic acid produces a marked competitive inhibition of the aminophenazone N-demethylation and the codeine phosphate O-demethylation by 9000 g-supernatant of rat liver homogenates, but it exerts virtually no effect on the aniline hydroxylation and the p-nitrophenol glucuronidation which are slightly inhibited only if its tenfold amount is allowed to react on the substrate.
摘要
丙戊酸对大鼠肝脏匀浆9000g上清液的氨基苯乙酮N-去甲基化和磷酸可待因O-去甲基化有明显的竞争性抑制作用，但对苯胺羟化作用和对硝基苯酚葡萄糖醛酸化作用几乎没有影响，只有当丙戊酸的量增加到10倍并与底物反应时，这两种反应才会受到轻微抑制。
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