Wilson I C, Prange A J, Lossen P T
Psychiatry Res. 1980 May;2(2):211-22. doi: 10.1016/0165-1781(80)90079-7.
In a double-blind crossover design we treated 20 normal women with thyrotropin-releasing hormone (TRH), 0.5 mg i.v., and saline in a random sequence. Both injections were preceded, 48 hours before, by a single dose of oral thyroid hormones (TH). TRH caused a shift toward mild euphoria, both on objective and subjective ratings. Although statistically significant, the effect was less than that observed in a previous study of normal women in which TH pretreatment was not used. Thus, TH pretreatment appeared partly to block psychological response to TRH. As expected, TH pretreatment also partly blocked thyroid-stimulating hormone (TSH) responses to TRH. Nevertheless, just as in our previous study, psychological responses were significantly negatively correlated with TSH responses. TH appears to exert two independent negative feedback effects: one on the brain (dimished psychological response); and one on the anterior pituitary (diminished TSH response).
在一项双盲交叉设计中，我们对20名正常女性进行了治疗，以随机顺序静脉注射0.5毫克促甲状腺激素释放激素（TRH）和生理盐水。在两次注射前48小时，均先给予单剂量口服甲状腺激素（TH）。TRH在客观和主观评分上均导致向轻度欣快感的转变。尽管具有统计学意义，但该效应小于先前一项未使用TH预处理的正常女性研究中观察到的效应。因此，TH预处理似乎部分阻断了对TRH的心理反应。正如预期的那样，TH预处理也部分阻断了促甲状腺激素（TSH）对TRH的反应。然而，正如我们先前的研究一样，心理反应与TSH反应显著负相关。TH似乎发挥了两种独立的负反馈作用：一种作用于大脑（心理反应减弱）；另一种作用于垂体前叶（TSH反应减弱）。
